Brief Biographical Sketch of

C. Michael Gibson M.S., M.D., F.A.C.C.

Dr. Gibson received his B.S., M.S., and M.D. degrees from the University of Chicago. He was an Intern, Resident and Chief Resident at the Brigham and Women’s Hospital, Harvard Medical School. He received his training as an interventional cardiologist and served as the Director of the Coronary Care Unit at Beth Israel Hospital, Harvard Medical School. Dr. Gibson then served as the Chief of Cardiology and Director of Interventional Cardiology at the West Roxbury Veterans Affairs Medical Center, Harvard Medical School. While at the West Roxbury VA, he also served as an Associate Physician at the Brigham and Women’s Hospital. He then moved on to Allegheny General Hospital as Vice Chairman of Medicine for Clinical Research and Director of Invasive Cardiology. He subsequently relocated to the west coast and served as Associate Chief of Cardiology, Chief of Interventional Cardiology and Director of the Cardiac Catheterization Laboratory at University of California San Francisco (UCSF). Dr. Gibson has now returned to Harvard’s Beth Israel Hospital as a full time interventional cardiologist. He is Associate Chief of Cardiology and Director of Academic Affairs in the Cardiovascular Division. Until 2003, Dr. Gibson served as Chief Academic Officer and Director of Core Services at Harvard Clinical Research Institute (HCRI).

Dr. Gibson’s work has largely focused on the development of the statistical and angiographic methods to investigate the pathophysiology of coronary artery disease and the efficacy of therapeutic modalities. He directs the angiographic core laboratory for a wide variety of studies including acute MI studies, unstable angina studies, interventional trials, peripheral interventional trials, angiogenesis trials (VEGF), imaging modality studies, managed care analyses for HCFA, and atherosclerosis regression trials such as the NIH-sponsored Harvard Atherosclerosis Reversibility Project (HARP). His work has been presented in over 350 manuscripts, abstracts, textbooks and textbook chapters.

Within the Thrombolysis In Myocardial Infarction (TIMI) Study Group, Dr. Gibson is a Principle Investigator of multiple international acute MI trials within the TIMI Study Chairman’s Office and is Director of the TIMI Data Coordinating Center. Dr. Gibson created the master database that unifies data from over 15 years of TIMI studies in over 50,000 patients. Dr. Gibson is also Director of the TIMI Angiographic Core Laboratory and invented the TIMI frame count (CTFC) in which the number of cineframes for dye to reach standardized distal landmarks is counted (an index of epicardial blood flow). Dr. Gibson also invented the TIMI myocardial perfusion grade (a measure of microvascular perfusion. The TIMI frame count and the TIMI myocardial perfusion grade are both multivariate predictors of 2 year mortality in acute MI, and are now widely used both clinically and in the assessment of new reperfusion strategies. Dr. Gibson recently introduced the concepts of the TIMI Angiographic Risk Score and the TIMI Myocardial Frame Count.

Dr. Gibson is on the editorial board of Circulation, the Journal of the American College of Cardiology (JACC), the Journal of Thrombosis and Thrombolysis and www.theheart.org. Dr. Gibson is Editor-in-Chief of www.clinicaltrialresults.org and www.timi.org which have had many millions of hits and slide downloads. As Associated Editor, he authors the summaries of cardiovascular clinical trials at the American College of Cardiology’s new website www.cardiosource.com. Over 500 trials are summarized there.

Dr. Gibson recently edited a new textbook, “Management Strategies in Interventional Cardiology” which is optimized for hand held devices. Dr. Gibson authors the chapter on Primary Angioplasty in Randomized Trials in Cardiovascular Disease published as a companion to Braunwald's Heart Disease. He co-authors the chapter “Recognition and Management of Patients with Stable Angina Pectoris in Braunwald and Goldman’s Primary Cardiology and co-authors the chapter Quantitative Coronary Arteriography in Topol’s textbook of Interventional Cardiology. He is lead author of the section on myocardial perfusion imaging in a new imaging textbook which is a companion to Braunwald’s Heart Disease.

Dr. Gibson lectures internationally on the topics of acute MI, acute coronary syndromes, atherosclerosis, interventional cardiology and angiogenesis.